Genetic syndromes of severe insulin resistance
نویسندگان
چکیده
منابع مشابه
Molecular genetics of severe insulin resistance.
Leprechaunism and type A diabetes represent inborn errors of insulin resistance whose phenotypes suggested causation by mutations in the insulin receptor gene. Cells cultured from patients with leprechaunism specifically lacked high-affinity insulin binding. Partial but different degrees of impairment were observed in cells cultured from first-degree relatives. Different mutations in the insuli...
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ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2018
ISSN: 0959-437X
DOI: 10.1016/j.gde.2018.02.002